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The Silent Threat: Non-Cancer Tumours Lurking in Your Pancreas - What You Need to Know

Non-cancer tumours in the pancreas, also known as benign tumours, pose a silent threat to individuals worldwide. While non-cancer tumours may not be as popular as their cancerous counterparts, it is crucial to understand their nature, symptoms, and available treatment options. This blog aims to raise awareness about non-cancerous pancreatic tumours, shedding light on their characteristics, symptoms, and treatment approaches.


Understanding Non-Cancerous Pancreatic Tumours


Non-cancer tumours, as the name suggests, are growths that do not have the ability to spread to other parts of the body. Unlike malignant tumours, they are localised and typically do not pose a threat to life. Within the pancreas, common non-cancerous tumours include pancreatic cysts and neuroendocrine tumours.


Pancreatic cysts are fluid-filled sacs that develop within the pancreas. They can happen due to various reasons, including congenital abnormalities or chronic pancreatitis. Pancreatic cysts often do not cause any symptoms and are discovered incidentally during imaging tests performed for unrelated conditions. 


While most pancreatic cysts are benign, a small percentage may have the potential to become cancerous over time. It is crucial to discern among the various types of pancreatic cysts like serous cystadenomas, intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, and solid pseudopapillary neoplasms, as each may have different implications and treatment approaches.


Neuroendocrine tumours (NETs) are another type of non-cancerous tumour that can develop in the pancreas. These tumours arise from the cells responsible for producing hormones in the pancreas, known as islet cells. NETs have the unique characteristic of secreting hormones, which can lead to distinct symptoms depending on the specific hormones released. 


Functioning NETs produce excessive amounts of hormones, leading to a range of symptoms, while non-functioning NETs do not secrete hormones and may remain asymptomatic until they reach a significant size.


Recognizing Non-Cancerous Pancreatic Tumour Symptoms


Non-cancerous pancreatic tumours often present with vague or no symptoms, making early detection challenging. However, some individuals may experience symptoms that warrant medical attention. Common symptoms include:


  1. Abdominal pain or discomfort: Pancreatic tumours can cause persistent or intermittent pain in the upper abdomen. The pain could radiate to the back and could be exacerbated after meals or during physical activity.
  2. Unexplained weight loss: Significant and unexplained weight loss can be a sign of pancreatic tumour development. This weight loss may occur even when the individual has a normal or increased appetite.
  3. Digestive issues: Non-cancerous pancreatic tumours can disrupt the normal functioning of the pancreas, affecting digestion. Symptoms may include indigestion, bloating, nausea, vomiting, or changes in bowel motions like diarrhoea or constipation.
  4. Jaundice: In some cases, non-cancerous tumours in the pancreas could block the bile duct, leading to jaundice. Jaundice is characterised by yellowing of your skin and eyes, dark urine, pale stools, and itching.


It is paramount to remember that these symptoms can also be indicative of other pancreatic conditions, such as pancreatic cancer or pancreatitis. Hence, it is paramount to consult a healthcare specialist for an accurate diagnosis.


Causes, Diagnosis, and Treatment for Pancreatic Cyst


Pancreatic cysts are among the most prevalent non-cancerous tumours found in the pancreas. While the exact causes of pancreatic cysts are not always clear, they can be linked to congenital abnormalities, chronic pancreatitis, or other factors.


The diagnosis of pancreatic cysts often involves imaging techniques like CT scans or MRI. These imaging tests help determine the size, location, and characteristics of the cysts. Endoscopic ultrasound (EUS) may also be used to obtain more detailed images of the cysts and surrounding tissues.


The treatment for pancreatic cyst depends on various factors, including the size, type, and risk of malignancy associated with the cysts. Small, asymptomatic cysts may be monitored through regular follow-up appointments and imaging scans. This treatment for pancreatic cyst, known as watchful waiting or surveillance, is often employed for low-risk cysts. The frequency of follow-up visits and imaging tests will depend on the characteristics of the cyst and the patient's individual circumstances.


However, larger cysts or those at risk of becoming cancerous may require intervention. Treatment options may include draining the cyst through a procedure called endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), which involves inserting a needle into the cyst to drain the fluid. 


In certain cases, surgical removal of the cyst or even a portion of the pancreas may be necessary. This is usually reserved for larger cysts, those causing symptoms, or those with worrisome features on imaging tests.


Neuroendocrine Tumours (NETs) of the Pancreas


Neuroendocrine tumours (NETs) are a less common but significant type of non-cancerous pancreatic tumour. These tumours originate from the islet cells in the pancreas that produce hormones. NETs can be classified as functioning or non-functioning, depending on whether they secrete hormones or not.


Functioning NETs produce excessive amounts of hormones such as insulin, glucagon, gastrin, or somatostatin. This hormonal excess can lead to a range of symptoms depending on the specific hormone involved. For example:

  1. Insulinomas: These functioning NETs produce excessive insulin, resulting in low blood sugar levels (hypoglycaemia). Symptoms may include dizziness, weakness, confusion, and even loss of consciousness.
  2. Glucagonomas: Glucagonomas produce excessive glucagon, leading to high blood sugar levels (hyperglycaemia). Symptoms may include increased thirst, frequent urination, weight loss, skin rash, and mouth sores.
  3. Gastrinomas: Gastrinomas produce excessive gastrin, causing the stomach to produce too much acid. This leads to the development of peptic ulcers in the stomach or small intestine. Symptoms include abdominal pain, heartburn, nausea, vomiting, and diarrhoea.


Non-functioning NETs do not secrete hormones, and as a result, they may remain asymptomatic until they reach a significant size. In such cases, symptoms may arise due to the tumour's mass effect on surrounding organs or if the tumour spreads to other parts of the body (metastasis).


The treatment of NETs involves a multidisciplinary approach. Depending on the size, location, and stage of the tumour, treatment options may include surgical removal, targeted therapies, hormone therapy, or a combination of these approaches. The appropriate treatment plan will be determined by the healthcare team and tailored to the individual patient's needs.


Non-Cancer Pancreatic Tumour Treatment and Prognosis


The treatment of non-cancerous pancreatic tumours requires an individualised approach, considering the specific type, size, and location of the tumour. Oncologists, surgeons, and other specialists collaborate to design the most suitable treatment strategy for each patient.


Regular follow-up appointments and imaging scans play a crucial role in monitoring the tumour's growth and ensuring timely intervention if necessary. Such visits typically include physical examinations as well as a varіеty of dіagnostic tests, such as blood tests and imaging tеsts lіkе CT scans, MRIs, or PET scans. 


Thе long-tеrm outlook for peoplе with non-cancerous pancrеatіc tumours is typically favourable, despite the potential difficulties brought on by thіs condition. Benign tumours, by definition, do not metastasize or spread to other organs. However, it is essential to remain vigilant and continue regular medical check-ups to ensure early detection of any changes or potential complications.




Non-cancerous tumours in the pancreas may be silent threats, but understanding their nature, symptoms, and treatment options empowers individuals to take control of their health. By recognizing the potential symptoms and seeking medical attention, when necessary, early detection and appropriate treatment can be achieved. The collaboration between medical professionals and patients is crucial in managing non-cancerous pancreatic tumours effectively. 


Medanta Medical Team
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