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Ductal or Lobular Hyperplasia

Breast cells can develop a precancerous condition called atypical hyperplasia. The term "atypical hyperplasia" refers to a build-up of aberrant cells in the breast's milk ducts and lobules.


Despite not being cancer, atypical hyperplasia raises the possibility of breast cancer. Atypical hyperplasia can develop into invasive or non-invasive breast cancer throughout your lifetime if abnormal cells build up in the milk lobules or ducts and grow more pronounced.


Future breast cancer development is more likely to happen if you have been diagnosed with atypical hyperplasia. To lower the risk of breast cancer, doctors frequently advise rigorous monitoring for the disease as well as certain drugs.



  • Atypical Ductal Hyperplasia (ADH): The lactiferous ducts in ADH are where the aberrant pattern of cell development occurs. Although it is not a pretty precancerous state, it is nonetheless associated with an increased risk of breast cancer in the future. When compared to individuals with all other proliferative breast diseases, those with ADH had the highest risk of getting invasive cancer. ADH is connected to non-invasive malignant ductal carcinoma in situ (DCIS) and could be regarded as an early stage of the disease. Both circumstances show that the premalignant cell alterations identified are in an early stage, and the outlook is favourable.

  • Atypical Lobular Hyperplasia (ALH): Within the breast lobules, atypical lobular hyperplasia takes place and is associated with an elevated risk of breast cancer later in life. Any extra lobular epithelial cells should be categorised under "lobular neoplasia" under current breast tumor categorization guidelines, which include ALH, lobular carcinoma in-situ (LCIS), and pleomorphic lobular carcinoma in-situ (PLCIS). Even though this classification is primarily for pathologists, patients typically obtain pathology reports that distinguish between these 3 categories. However, in terms of prognosis, therapy, or subsequent risk of acquiring cancer in the future, there may not be much of a difference between these diverse forms of lobular neoplasia.


Alarming factors:


Atypical hyperplasia's origin is unknown.


Breast cells that have an aberrant quantity, size, shape, growth pattern, or appearance are called atypical hyperplasia. The kind of atypical hyperplasia is determined by the morphology of the aberrant cells:


  1. Breast duct aberrant cells are referred to as atypical ductal hyperplasia
  2. Breast lobules containing aberrant cells are known as atypical lobular hyperplasia


It is believed that atypical hyperplasia is a component of the intricate cell transition that might lead to the accumulation and development of breast cancer.




Typically, atypical hyperplasia does not manifest any particular symptoms. If you experience any signs or symptoms, schedule a visit with your doctor.


Atypical hyperplasia is discovered when a breast biopsy is performed to look into an anomaly that was seen on mammography or ultrasound. When a biopsy is performed to look into a breast condition, such as a tumor or nipple discharge, atypical hyperplasia may occasionally be found.




Although hyperplasia seldom results in a lump that can be felt, it can occasionally result in alterations that can be observed on a mammogram. It is diagnosed by performing a biopsy, in which part of the aberrant breast tissue is removed surgically or with a hollow needle to be tested.




Surgery is used to completely remove the tissue from the place where the abnormal cells were discovered. After a final examination of the breast tissue that was removed, cancer may be discovered in up to 20% of instances. Increased screening is advised following surgery. 


You will have clinical breast examinations every six months and mammograms every year. You will have breast imaging every six months if you have yearly high-risk screening MRIs as an adjuvant, which some patients may also receive. 


Based on your risk factors, your medical breast expert will assist assess if you are eligible for an annual breast MRI. If you are a lady with thick breast tissue, an MRI is extremely beneficial.




It is beneficial to become acquainted with your breast tissue to detect abnormalities that need to be mentioned to your provider. Dedicate yourself to self-breast awareness, commonly known as self-breast checks. 

Breast cancer risk factors include obesity. Reduced risk can be achieved by maintaining a healthy weight and an active way of life. Alcohol use is an underappreciated risk factor for breast cancer. 

Regular consumption of alcoholic drinks can raise the risk of breast cancer by an extra 15%. As a result, limit your alcohol consumption to no more than one glass each day. Smoking is an established risk factor for many cancers and diseases, not just breast cancer. Try your best to refrain from smoking, even passive smoking.

Dr Rajeev Agarwal
Cancer Care
Meet The Doctor
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