Osteosarcoma is a relatively rare primary malignant tumour of the bone with an estimated global incidence of 3.4 cases per million population. Although osteosarcoma is rare in the overall population, it is the most common bone cancer in children and young adults. Conventional osteosarcoma comprises about 80% of all osteosarcoma cases and usually affects young adults with peak incidence age of 10-30 years; it is more common in men than in women.
The past century has seen an improvement in survival rates with life expectancy rising from a mere 20% in the early part of the 20th century to about 65% in the recent years. The current management of osteosarcoma in early stages of the disease focuses on chemotherapy and limb salvage.