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Paediatric Bone Marrow Transplant Highlights
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World-renowned bone marrow transplant specialists pioneering new techniques
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High-volume centre for half-match transplants matching international success rate
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State-of-the-art centre with 24x7 blood bank support, advanced infrastructure
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Expertise in HLA-matching techniques optimising donor compatibility
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Dedicated paediatric team, PICU and multi-disciplinary support for complex illnesses
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Among top care centres for relapse or refractory blood cancer in children
Our Chairman Message
The Medanta Paediatric BMT Division is dedicated to improving the lives of children with blood disorders like Thalassemia, cancers, immune disorders. We are driven to offer hope to parents and add life to years for our young patients through innovative curative treatments.
Ailments
Team approach and compassionate care for holistic heart health.
Inherited Blood Disorders
Inherited blood disorders such as Thalassemia and Sickle Cell Disease (SCD) significantly impact the production and function of haemoglobin, the protein in red blood cells responsible for oxygen transport.
Thalassemia affects the body's ability to produce haemoglobin. There are two main types: alpha and beta-thalassemia. The severity of symptoms varies depending on the type and number of gene mutations inherited. Individuals may experience mild to severe anaemia, leading to symptoms like fatigue, weakness, and shortness of breath. Management includes regular blood transfusions and chelation therapy to remove excess iron from the body.
SCD is a group of inherited disorders that cause abnormal haemoglobin. The most common form is Sickle Cell Anaemia. In SCD, red blood cells become sickle-shaped, stiff, and sticky, leading to a shortage of healthy red blood cells. These sickle cells can block blood flow in small vessels, causing severe pain and complications such as infections, acute chest syndrome, and stroke.
Both Thalassemia and SCD can be cured with Bone Marrow Transplant to improve quality of life and longevity.
Inborn Errors of Metabolism
Inborn errors of metabolism (IEM) are a group of rare genetic disorders caused by defects in specific enzymes that affect the body's ability to convert food to energy. These enzyme deficiencies can lead to the accumulation of toxic substances or the deficiency of critical compounds, disrupting normal bodily functions. A few of them are Lysosomal storage disorders, Galactosemia, Maple syrup urine disease (MSUD), Phenylketonuria (PKU). Symptoms vary widely but may include developmental delays, weight loss, neurological issues, feeding difficulties, failure to thrive.
Diagnosis typically involves newborn screening, genetic testing, and metabolic assays. Treatment depends on the specific disorder and may include dietary modifications, enzyme replacement therapy, and medications to manage symptoms and prevent complications.
Primary immunodeficiency
Primary immunodeficiency disorders (PI) are a group of over 300 genetic disorders that impair the immune system’s ability to defend against infections. Individuals with PI have defects in the cells or proteins that make up the immune system, leading to frequent, severe, or unusual infections. Symptoms can range from mild to severe and may include recurrent respiratory infections, gastrointestinal issues, skin infections, and failure to thrive in infants.
Diagnosing PI often involves a combination of clinical evaluation, family history, and specialized laboratory tests. Treatment varies depending on the specific disorder but may include immunoglobulin replacement therapy, antibiotics to prevent and treat infections, and in some cases, hematopoietic stem cell transplantation to correct the underlying immune defect.
Latest Technology
Smart systems and cutting-edge technology that drive seamless experiences.
- CD45RA Depletion
- Blood and Bone Marrow Stem Cell Collection
- TCR Alpha-Beta Depletion
- CAR T Cell Therapy
- Donor Lymphocyte Infusion
CD45RA Depletion
CD45RA Depletion is a specialised technique used in allogeneic hematopoietic stem cell transplantation and cell therapy. CD45RA is a marker found on naïve T cells, which have not yet encountered antigens. Depleting these cells from donor grafts helps to reduce the risk of graft-versus-host disease (GVHD), a common complication where the donor's immune cells attack the recipient's tissues. This technique is beneficial for patients with high-risk leukaemia, aplastic anaemia, and inherited metabolic disorders. In the context of CAR-T cell therapy, CD45RA depletion can be employed to enhance the safety and efficacy of the treatment by minimising the risk of GVHD. It is also applied in virus-specific T-cell therapies to selectively expand memory T cells that can combat infections post-transplantation. A technical complex procedure, it requires sophisticated equipment and expertise, making it available only in specialized centers
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