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Goodpasture Syndrome

Goodpasture syndrome or GPS is an autoimmune disorder, which affects the underlying membranes of the kidney and liver. The disease occurs when the body’s defense system produces antibodies against col..

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Goodpasture syndrome or GPS is an autoimmune disorder, which affects the underlying membranes of the kidney and liver. The disease occurs when the body’s defense system produces antibodies against collagen and attacks lungs and kidneys. Collagen is a type of protein, which helps in the formation of connectivity tissues. Goodpasture syndrome is also known as antiglomerular basement antibody disease or anti-GBM. The initial symptoms of the disease are mild and misleading, such as fatigue, etc., which are common with other disorders too. If not diagnosed and treated on time, it is fatal and can even claim life.

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Goodpasture Syndrome
Symptoms
Symptoms

The symptoms of the disease may begin to show slowly over a period of time, but develops rapidly within days and weeks. The signs of the disease are:

  • Loss of appetite, weakness, and fatigue.
  • Nausea and vomiting.
  • Difficulty in breathing, as it affects the lungs.
  • Change of skin color (blue or pale).
  • Cough with sputum or mucus, tinged with blood.
  • Change of color of urine.
  • Swelling in legs because of high blood pressure.
  • Frequent urinary infection causing burning sensation when urinating.
  • Frothy or foamy urine, often with blood.
  • Severe back pain especially below the ribs.
  • Swelling in the hands and feet.

Causes
Causes

The causes of immune disorders have not been clearly understood by researchers till date. The primary reason for the disease is identified as genetic or family history. However, the factors that increase the risk of GPS include:

  • Exposure to chemicals and fumes such as hydrocarbon solvents.
  • Regular intake of marijuana cause damage to the lungs and weakens the immune system.
  • Any type of contact with metallic dust.
  • Usage or consumption of drugs such as morphine or cocaine in any form or quantity.
  • Smoking and alcohol further affect our immunity system making us more susceptible to GBM (glioblastoma multiforme).
  • Viral infections such as flu and cold.
  • Individuals between the age 20 – 30 and above 60 are at an easy risk of the disease.
  • Gender: Young men are at a greater risk of developing the disease.

Risks
Risks

If untreated, condition can result in:

  • Kidney damage or failure which can be chronic or end stage.
  • Lung failures.
  • Progressive glomerulonephritis (a syndrome of the kidney that is characterized by a rapid loss of renal function).
  • Pulmonary hemorrhage or lung bleeding which could be severe.

Prevention
Prevention

Following are some measure that can be followed to prevent GPS:

  • Avoid smoking.
  • Decrease alcohol intake.
  • Adopt a healthy lifestyle.
  • Exercise to stay fit.

Doctors, Pioneers, Life Savers

Our superspecialist doctors provide the highest quality of care through a team-based, doctor-led model. Trained at some of the world's most renowned institutions, our highly experienced doctors are distinguished experts in their respective specialities. Our doctors work full-time and exclusively across Medanta hospitals. In addition to offering superspecialised care in their own field, the Medanta organisational structure enables every doctor to help create a culture of collaboration and multispecialty care integration.

Our superspecialist doctors provide the highest quality of care through a team-based, doctor-led model. Trained at some of the world's most renowned i..... Continue Reading

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